Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

Xiaohong R Yang; Jenny Chang-Claude; Ellen L Goode; Fergus J Couch; Heli Nevanlinna; Roger L Milne; Mia Gaudet; Marjanka K Schmidt; Annegien Broeks; Angela Cox; Peter A Fasching; Rebecca Hein; Amanda B Spurdle; Fiona Blows; Kristy Driver; Dieter Flesch-Janys; Judith Heinz; Peter Sinn; Alina Vrieling; Tuomas Heikkinen; Kristiina Aittomaeki; Paeivi Heikkilae; Carl Blomqvist; Jolanta Lissowska; Beata Peplonska; Stephen Chanock; Jonine Figueroa; Louise Brinton; Per Hall; Kamila Czene; Keith Humphreys; Hatef Darabi; Jianjun Liu; Laura J Van 't Veer; Flora E Van Leeuwen; Irene L Andrulis; Gord Glendon; Julia A Knight; Anna Marie Mulligan; Frances P O'Malley; Nayana Weerasooriya; Esther M John; Matthias W Beckmann; Arndt Hartmann; Sebastian B Weihbrecht; David L Wachter; Sebastian MS Jud; Christian R Loehberg; Laura Baglietto; Dallas R English; Graham G Giles; Catriona A McLean; Gianluca Severi; Diether Lambrechts; Thijs Vandorpe; Caroline Weltens; Robert Paridaens; Ann Smeets; Patrick Neven; Hans Wildiers; Xianshu Wang; Janet E Olson; Victoria Cafourek; Zachary Fredericksen; Matthew Kosel; Celine Vachon; Helen E Cramp; Daniel Connley; Simon S Cross; Sabapathy P Balasubramanian; Malcolm WR Reed; Thilo Doerk; Michael Bremer; Andreas Meyer; Johann H Karstens; Aysun Ay; Tjoung-Won Park-Simon; Peter Hillemanns; Jose Ignacio Arias Perez; Primitiva Menendez Rodriguez; Pilar Zamora; Javier Bentez; Yon-Dschun Ko; Hans-Peter Fischer; Ute Hamann; Beate Pesch; Thomas Bruening; Christina Justenhoven; Hiltrud Brauch; Diana M Eccles; William J Tapper; Sue M Gerty; Elinor J Sawyer; Ian P Tomlinson; Angela Jones; Michael Kerin; Nicola Miller; Niall McInerney; Hoda Anton-Culver; Argyrios Ziogas; Chen-Yang Shen; Chia-Ni Hsiung; Pei-Ei Wu; Show-Lin Yang; Jyh-Cherng Yu; Shou-Tung Chen; Giu-Cheng Hsu; Christopher A Haiman; Brian E Henderson; Loic Le Marchand; Laurence N Kolonel; Annika Lindblom; Sara Margolin; Anna Jakubowska; Jan Lubinski; Tomasz Huzarski; Tomasz Byrski; Bohdan Gorski; Jacek Gronwald; Maartje J Hooning; Antoinette Hollestelle; Ans MW van den Ouweland; Agnes Jager; Mieke Kriege; Madeleine MA Tilanus-Linthorst; Margriet Collee; Shan Wang-Gohrke; Katri Pylkaes; Arja Jukkola-Vuorinen; Kari Mononen; Mervi Grip; Pasi Hirvikoski; Robert Winqvist; Arto Mannermaa; Veli-Matti Kosma; Jaana Kauppinen; Vesa Kataja; Paeivi Auvinen; Ylermi Soini; Reijo Sironen; Stig E Bojesen; David Dynnes Orsted; Diljit Kaur-Knudsen; Henrik Flyger; Borge G Nordestgaard; Helene Holland; Georgia Chenevix-Trench; Siranoush Manoukian; Monica Barile; Paolo Radice; Susan E Hankinson; David J Hunter; Rulla Tamimi; Suleeporn Sangrajrang; Paul Brennan; James Mckay; Fabrice Odefrey; Valerie Gaborieau; Peter Devilee; PEA Huijts; RAEM Tollenaar; C Seynaeve; Gillian S Dite; Carmel Apicella; John L Hopper; Fleur Hammet; Helen Tsimiklis; Letitia D Smith; Melissa C Southey; Manjeet K Humphreys; Douglas Easton; Paul Pharoah; Mark E Sherman; Montserrat Garcia-Closas

Journal article

Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

Xiaohong R Yang, Jenny Chang-Claude, Ellen L Goode, Fergus J Couch, Heli Nevanlinna, Roger L Milne, Mia Gaudet, Marjanka K Schmidt, Annegien Broeks, Angela Cox, Peter A Fasching, Rebecca Hein, Amanda B Spurdle, Fiona Blows, Kristy Driver, Dieter Flesch-Janys, Judith Heinz, Peter Sinn, Alina Vrieling, Tuomas Heikkinen Show all

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2011

DOI: 10.1093/jnci/djq526

Abstract

BACKGROUND: Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. METHODS: We pooled tumor marker and epidemiological risk factor data from 35,568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case-case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case-control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statisti..

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University of Melbourne Researchers

Graham Giles Author Melbourne School of Population and Global Health

Laura Baglietto Author Melbourne School of Population and Global Health

Catriona McLean Author Florey Department of Neuroscience and Mental Health

John Hopper Author Melbourne School of Population and Global Health

Dallas English Author Melbourne School of Population and Global Health

Related Projects (2)

Epidemiology of chronic disease, health interventions and DNA studies

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NIH AUSTRALIAN BREAST CANCER FAMILY REGISTRY SOUTHEY-HOPPER

Grants

Awarded by European Community

Awarded by National Cancer Institute (NCI), National Institutes of Health (NIH)

Awarded by Cancer Care Ontario

Awarded by Northern California Cancer Center

Awarded by University of Melbourne

Awarded by Fondo de Investigacion Sanitario

Awarded by Federal Ministry of Education and Research (BMBF) Germany

Awarded by Deutsche Krebshilfe

Awarded by state of Baden-Wurttemberg through the Medical Faculty of the University of Ulm

Awarded by Academy of Finland

Awarded by European Union Framework Programme 6

Awarded by Stichting tegen Kanker

Awarded by NHMRC

Awarded by NIH

Awarded by NCI

Awarded by Cancer Research UK

Awarded by National Institute for Health Research

Awarded by The Francis Crick Institute

Awarded by NATIONAL CANCER INSTITUTE

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

This study was supported in part by the European Community's Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175). The individual Breast Cancer Association Consortium (BCAC) studies were funded by the following sources: Australian Breast Cancer Family Study (ABCFS) and Ontario Familial Breast Cancer Registry (OBCFR): National Cancer Institute (NCI), National Institutes of Health (NIH) under RFA CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR) and Principal Investigators, including Cancer Care Ontario (U01 CA69467), Northern California Cancer Center (U01 CA69417), and University of Melbourne (U01 CA69638).Breast Cancer in Galway Genetic Study (BIGGS): E.J.S. is funded by the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London.Copenhagen General Population Study (CGPS): The Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council, and Copenhagen University Hospital, Herlev Hospital.Spanish National Cancer Centre Breast Cancer Study (CNIO-BCS): The Red Tematica de Investigacion Cooperativa en Cancer and grants from the Asociacion Espanola Contra Cancer and the Fondo de Investigacion Sanitario PI081120 to J.B. and PI081583 to R.L.M.).Gene Environment Interaction and Breast Cancer in Germany (GENICA): Federal Ministry of Education and Research (BMBF) Germany (01KW9975/5, 01KW9976/8, 01KW9977/0, and 01KW0114), the Robert Bosch Foundation of Medical Research, Stuttgart, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, as well as the Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.Genetic Epidemiology Study of Breast Cancer by Age 50 (GESBC): Deutsche Krebshilfe (70492) and the state of Baden-Wurttemberg through the Medical Faculty of the University of Ulm (P. 685).Helsinki Breast Cancer Study (HEBCS): The Helsinki University Central Hospital Research Fund, Academy of Finland (110663), the Finnish Cancer Society, and the Sigrid Juselius Foundation.Leuven Multidisciplinary Breast Centre (LMBC): European Union Framework Programme 6 Project LSHC-CT-2003-503297 (the Cancerdegradome) and by the 'Stichting tegen Kanker' (232-2008).Karolinska Breast Cancer Study (KARBAC): The Swedish Cancer Society, the Gustav V Jubilee Foundation, the Cancer Society in Stockholm, and the Bert von Kantzow Foundation.Kuopio Breast Cancer Project (KBCP): The Kuopio University Central EVO Research Fund, Academy of Finland, the Finnish Cancer Society, the University of Kuopio and EVO research funding of Vaasa Hospital District.Kathleen Cuningham Foundation Consortium for research into Familial Breast Cancer (kConFab): NHMRC (145684, 288704 and 454508), the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. A. B. S. is supported by an NHMRC Senior Research Fellowship, and G. C.-T. by an NHMRC Senior Principal Research Fellowship.Mammary Carcinoma Risk Factor Investigation (MARIE): Deutsche Krebshilfe e. V. (70-2892-BR I), the Hamburg Cancer Society, and the German Cancer Research Center.Mayo Clinic Breast Cancer Study (MCBCS): NIH (CA122340), NIH recovery act (ARRA CA122340Z), and an NCI-sponsored Specialized Program Of Research Excellence (SPORE) Breast Cancer to the Mayo Clinic CA116201).Melbourne Collaborative Cohort Study (MCCS): The Cancer Council Victoria, VicHealth, and NHMRC (209057, 251533, 396414, 504711).Multiethnic Cohort (MEC): NIH (R01-CA63464 and R37-CA54281).Nurses Health Study (NHS): NIH (CA87969).Oulu Breast Cancer Study (OBCS): Finnish Cancer Foundation, the Sigrid Juselius Foundation, the Academy of Finland, the University of Finland, and Oulu University Hospital.Leiden University Medical Centre Breast Cancer Study (ORIGO): The Dutch Cancer Society.Polish Breast Cancer Study (PBCS): Intramural Research Program of US NIH, NCI, Division of Cancer Epidemiology and Genetics (DCEG).