Validation of two Framingham cardiovascular risk prediction algorithms in an Australian population: The ‘old’versus the ‘new’Framingham equation

Abstract

Background: Multivariable risk prediction equations attempt to quantify an individual's cardiovascular risk. Those borne from the Framingham Heart Study remain the most well-established and widely used. In February 2008, a new Framingham risk equation was published. We sought to determine the differences between the most commonly used Framingham equation from 1991 and the 2008 version through their application to a contemporary Australian population. Methods and results: The two risk equations were applied to 7329 individuals from the Australian Diabetes, Obesity and Lifestyle study. All individuals were aged 30–74 years and free of cardiovascular disease. Differences in median risk scores w..