Serum Apolipoprotein AI and B Are Stronger Biomarkers of Diabetic Retinopathy Than Traditional Lipids
Muhammad Bayu Sasongko, Tien Y Wong, Thanh T Nguyen, Ryo Kawasaki, Alicia Jenkins, Jonathan Shaw, Jie Jin Wang
Diabetes Care | AMER DIABETES ASSOC | Published : 2011
OBJECTIVE: To describe and compare the associations of serum lipoproteins and apolipoproteins with diabetic retinopathy. RESEARCH DESIGN AND METHODS: This was a cross-sectional study of 224 diabetic patients (85 type 1 and 139 type 2) from a diabetes clinic. Diabetic retinopathy was graded from fundus photographs according to the Airlie House Classification system and categorized into mild, moderate, and vision-threatening diabetic retinopathy (VTDR). Serum traditional lipids (total, LDL, non-HDL, and HDL cholesterol and triglycerides) and apolipoprotein AI (apoAI), apolipoprotein B (apoB), and the apoB-to-apoAI ratio were assessed. RESULTS: Diabetic retinopathy was present in 133 (59.4%) in..View full abstract
This study was supported by a Diabetes Australia Research Trust Grant (to T.Y.W., J.S., T.T.N., and J.J.W.).