Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn E Quin, Elaine Sanij, Megan J Bywater, Ross D Hannan, David Ryckman, Kenna Anderes, William G Rice
Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2011
This work was supported in part by Cylene Pharmaceuticals Inc. and in part by grants to R.D. Hannan and E. Sanij from the National Health and Medical Research Council (NHMRC) of Australia. R.D. Hannan was supported by a research fellowship from the NHMRC. M.J. Bywater was supported by an NHMRC postgraduate scholarship. J.E. Quin was supported by an Australian postgraduate award.