Journal article
Shape analysis of the neostriatum in subtypes of frontotemporal lobar degeneration: Neuroanatomically significant regional morphologic change
JCL Looi, M Walterfang, M Styner, M Niethammer, LA Svensson, O Lindberg, P Östberg, L Botes, E Örndahl, P Chua, D Velakoulis, LO Wahlund
Psychiatry Research Neuroimaging | ELSEVIER IRELAND LTD | Published : 2011
Abstract
Frontostriatal circuit mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD) and may differ across subtypes of FTLD. We manually segmented the neostriatum (caudate nucleus and putamen) in FTLD subtypes: behavioral variant frontotemporal dementia, FTD, n=12; semantic dementia, SD, n=13; and progressive non-fluent aphasia, PNFA, n=9); in comparison with controls (n=27). Diagnoses were based on international consensus criteria. Manual bilateral segmentation of the caudate nucleus and putamen was conducted blind to diagnosis by a single analyst, on MRI scans using a standardized protocol. Intracranial volume was calculated via a stereological point counti..
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Funding Acknowledgements
This research made use of the SMILE medical imaging laboratory at Karolinska University Hospital, Stockholm, Sweden. Christian Andersen, MD, performed neurological assessments for diagnosis of FTLD subtypes. Bram B. Zandbelt assisted with volumetric data extraction and analysis and stereologic intracranial volume measurements. JCLL thanks the Canberra Hospital Specialists Private Practice Trust Fund and ACT Health for partial leave and travel support for the duration of this project, with the remainder of costs self-funded. PO's contribution was supported by a grant from the Gun and Bertil Stohne Foundation. We thank all the patients and volunteers.