Journal article

Pituitary volume prospectively predicts internalizing symptoms in adolescence

Amy R Zipursky, Sarah Whittle, Murat Yuecel, Valentina Lorenzetti, Stephen J Wood, Dan I Lubman, Julian G Simmons, Nicholas B Allen



BACKGROUND: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed to investigate whether pituitary volume, an index of hypothalamic-pituitary-adrenal (HPA) axis function, represents a vulnerability factor for the emergence of internalizing and externalizing symptoms during adolescence using a prospective, longitudinal design. METHODS: One hundred and fifty-five adolescents completed 3T structural magnetic resonance imaging (MRI), symptom rating scales and a diagnostic interview during early adolescence (M age 12.6 years, SD .5 years); symptom rating scales were re-administered approximately three years later (M age 15.2 years). T..

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Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council

Awarded by NHMRC

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241) and the Australian Research Council (Discovery Grant DP0878136). Dr Whittle is supported by an Australian Research Council Postdoctoral Fellowship. Dr Yucel is supported by an NHMRC Clinical Career Development Award (ID: 509345). Ms Lorenzetti is supported by an Endeavour International Postgraduate Research Scholarship (IPRS) and a Melbourne International Research Scholarship (MIRS). Dr Lubman is supported by the Colonial Foundation. Dr Wood is supported by a Clinical Career Development Award from the NHMRC (628711), and a Young Investigator Award from NARSAD.Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors would like to thank the Brain Research Institute for support in acquiring the neuroimaging data, and the adolescents who participated in the study.