Journal article
KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer
J Tie, L Lipton, J Desai, P Gibbs, RN Jorissen, M Christie, KJ Drummond, BNJ Thomson, V Usatoff, PM Evans, AW Pick, S Knight, PWG Carne, R Berry, A Polglase, P McMurrick, Q Zhao, D Busam, RL Strausberg, E Domingo Show all
Clinical Cancer Research | Published : 2011
Abstract
Purpose: Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. Experimental Design: One hundred colorectal cancer metastases were screened for mutations in 19 oncogenes, and further 61 metastases and 87 matched primary cancers were analyzed for genes with identified mutations. Mutation prevalence was compared between (a) metastases from liver (n = 65), lung (n = 50), and brain (n = 46), (b) metastases and matched primary cancers, and (c) metastases and an independent cohort of primary cancers (n = 604). Mutations dif..
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Awarded by NHMRC
Awarded by Victorian Cancer Agency
Funding Acknowledgements
This work was supported by the Jeannik M. Littlefield-AACR Grant in Metastatic Colon Cancer Research (L. Lipton, P. Gibbs, O.M. Sieber), the Hilton Ludwig Cancer Metastasis Initiative (L. Lipton, P. Gibbs, O.M. Sieber), the CSIRO Preventative Health Flagship (L. Lipton, P. Gibbs, O.M. Sieber), the NHMRC through a Medical and Dental Postgraduate Research Scholarship (Application ID 487925; J. Tie), the Victorian Government through a Victorian Cancer Agency Clinical Researcher Fellowship (L. Lipton), the Cancer Council Victoria through a Postgraduate Cancer Research Scholarship (M. Christie), the Operational Infrastructure Support Program (P. Gibbs, O.M. Sieber), Victorian Cancer Agency Translational Cancer Research Funding (Application ID EOI09_32; P. Gibbs), and the Oxford Comprehensive Biomedical Research Centre (E. Domingo, I.P.M. Tomlinson).