Damaging effects of ischemia/reperfusion on intestinal muscle
Louise Pontell, Purnima Sharma, Leni R Rivera, Michelle Thacker, Yan Hong Tan, James A Brock, John B Furness
Cell and Tissue Research | SPRINGER | Published : 2011
Periods of ischemia followed by restoration of blood flow cause ischemia/reperfusion (I/R) injury. In the intestine, I/R damage to the mucosa and neurons is prominent. Functionally, abnormalities occur in motility, most conspicuously a slowing of transit, possibly as a consequence of damage to neurons and/or muscle. Here, we describe degenerative and regenerative changes that have not been previously reported in intestinal muscle. The mouse small intestine was made ischemic for 1 h, followed by re-perfusion for 1 h to 7 days. The tissues were examined histologically, after hematoxylin/eosin and Masson's trichrome staining, and by myeloperoxidase histochemistry to detect inflammatory reaction..View full abstract
Dr. Purnima Sharma was supported by an Endeavour Fellowship awarded by the Australian Government.