The 5-HT2A/1A Agonist Psilocybin Disrupts Modal Object Completion Associated with Visual Hallucinations
Michael Kometer, B Rael Cahn, David Andel, Olivia L Carter, Franz X Vollenweider
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2011
BACKGROUND: Recent findings suggest that the serotonergic system and particularly the 5-HT2A/1A receptors are implicated in visual processing and possibly the pathophysiology of visual disturbances including hallucinations in schizophrenia and Parkinson's disease. METHODS: To investigate the role of 5-HT2A/1A receptors in visual processing the effect of the hallucinogenic 5-HT2A/1A agonist psilocybin (125 and 250 μg/kg vs. placebo) on the spatiotemporal dynamics of modal object completion was assessed in normal volunteers (n = 17) using visual evoked potential recordings in conjunction with topographic-mapping and source analysis. These effects were then considered in relation to the subject..View full abstract
This work was supported by the Swiss Neuromatrix Foundation, Switzerland (MK, FXV) and the Heffter Research Institute, Santa Fe, New Mexico (RC, DA). We thank R.D. Pascual-Marqui for his technical support and for the development of LORETA software package. All authors report no biomedical financial interests or potential conflicts of interest with respect to this study.