Journal article

Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness

Madhara Udawela, Elizabeth Scarr, Anthony J Hannan, Elizabeth A Thomas, Brian Dean

Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2011

Abstract

OBJECTIVE: Our recent microarray study detected decreases in the expression of phospholipase C beta 1 mRNA in the dorsolateral prefrontal cortex from subjects with schizophrenia at different stages of illness. Thus we aimed to validate and extend these findings. METHOD: We measured levels of mRNA and protein for phospholipase C beta 1 variant a and b using real-time PCR and western blot analysis, respectively, in the dorsolateral prefrontal cortex from subjects with schizophrenia, who had a short ( 22 years) duration of illness. RESULTS: Compared to age/sex matched controls, levels of phospholipase C beta 1 variant a and b mRNAs were decreased (-33% and -50%, respectively) in short duration ..

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Funding Acknowledgements

Brian Dean is a National Health and Medical Research Council Senior Research Fellow (400016). Elizabeth Scarr is the ARH Royce Abbey Post-Doctoral Fellow. This research was supported by Operational Infrastructure Support (OIS) from the Victorian State Government. Tissues were received from the Victorian Brain Bank Network, supported by the Mental Health Research Institute of Victoria, Alfred Hospital, the University of Melbourne and the Victorian Forensic Institute of Medicine and funded by Australia's National Health and Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services. The authors alone are responsible for the content and writing of the paper.