Neurodevelopmental and perinatal correlates of simple brain metrics in very preterm infants

Abstract

Objective: To explore perinatal correlates of 3 simple measures of brain size, known as metrics, in very preterm infants at term-equivalent age and their relationship to 2-year neurodevelopmental outcomes. Design: Prospective cohort study of preterm infants born at a gestational age of less than 30 weeks or a weight of less than 1250 g between April 1, 2001, and December 31, 2003, and followed up at 2 years of corrected age. Setting: The Royal Women's Hospital and the magnetic resonance imaging unit at the Royal Children's Hospital. Patients: Two hundred thirty-six preterm infants. Interventions: Brain metrics - biparietal, bifrontal, and transverse cerebellar diameters - on magnetic resonan..