Journal article
Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor
CF Neoh, L Leung, A Misra, RB Vajpayee, GE Davies, RO Fullinfaw, K Stewart, DCM Kong
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2011
DOI: 10.1128/AAC.01175-10
Abstract
Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Grants
Funding Acknowledgements
The support from study participants, the RVEEH Day Surgery Unit nursing staff, pharmacy staff, and Dermot Cassidy is gratefully acknowledged. We thank Merck Sharp & Dohme (Australia) Pty. Limited for the provision of pure substance caspofungin. We thank Jian Li and Hui He for their input in developing the analytical assay for caspofungin.This study was supported by the Contributing to Australian Scholarship and Science (CASS) Foundation. Scholarship support to C.F.N. by the University of Technology MARA is acknowledged.