Journal article

Hippocampus, amygdala and global brain changes 10 years after childhood traumatic brain injury

MH Beauchamp, M Ditchfield, JJ Maller, C Catroppa, C Godfrey, JV Rosenfeld, MJ Kean, VA Anderson

International Journal of Developmental Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2011

Abstract

Traumatic brain injury (TBI) in children results in damage to the developing brain, particularly in severely injured individuals. Little is known, however, of the long-term structural aspects of the brain following childhood TBI. This study investigated the integrity of the brain 10 years post-TBI using magnetic resonance imaging volumetrics in a sample of 49 participants with mild, moderate and severe TBI, evaluated against a normative sample of 20 individuals from a pediatric database with comparable age and gender distribution. Structural integrity was investigated in gray and white matter, and by manually segmenting two regions of interest (hippocampus, amygdala), potentially vulnerable ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Institute of Neurological Disorders and Stroke


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (project grant no. 284518) and by the Canadian Institutes of Health Research, Thrasher Research Fund, and Lynne Quayle Charitable Fund (MHB). The funding sources were not involved in the study design, collection, analysis or interpretation of data or writing of the manuscript.Comparison group data used in the preparation of this article were obtained from the Pediatric MRI Data Repository (third release, 10/2009) created by the NIH MRI Study of Normal Brain Development. This is a multi-site, longitudinal study of typically developing children, from ages newborn through young adulthood, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke (Contract #s N01-HD02-3343, N01-MH9-0002, and N01-NS-9-2314, -2315, -2316, -2317, -2319 and -2320). A listing of the participating sites and a complete listing of the study investigators can be found at http://www.bic.mni.mcgill.ca/nihpd/info/participating_centers.html.