Journal article

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

GM Newnham, M Conron, S McLachlan, A Dobrovic, H Do, J Li, K Opeskin, N Thompson, GM Wright, DM Thomas

BMC Cancer | BMC | Published : 2011

Abstract

BACKGROUND: The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. METHODS: Both transcriptional and genomic profiling were performed on 69 resected NSCLC specimens and results correlated with mutational analyses and clinical data to identify genetic alterations associated with groups of interest. RESULTS: Combined analyses identified specific patterns of genetic alteration associated with adenocarcinoma vs. squamous differentiation; KRAS mutation; TP53 mutation, metastatic potenti..

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