Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
GM Newnham, M Conron, S McLachlan, A Dobrovic, H Do, J Li, K Opeskin, N Thompson, GM Wright, DM Thomas
BMC Cancer | BMC | Published : 2011
BACKGROUND: The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. METHODS: Both transcriptional and genomic profiling were performed on 69 resected NSCLC specimens and results correlated with mutational analyses and clinical data to identify genetic alterations associated with groups of interest. RESULTS: Combined analyses identified specific patterns of genetic alteration associated with adenocarcinoma vs. squamous differentiation; KRAS mutation; TP53 mutation, metastatic potenti..View full abstract
The authors would like to acknowledge the assistance of Michael Krypuy from the Department of Pathology, Peter MacCallum Cancer Centre in undertaking high resolution melting analysis for KRAS mutations. Funding for this project was received from The University of Melbourne (scholarship for Dr G Newnham), the Australasian Society of Cardiac and Thoracic Surgeons Foundation, and The National Health and Medical Research Council of Australia.