Journal article
The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals
PS Donnelly
Journal of the Chemical Society Dalton Transactions | ROYAL SOC CHEMISTRY | Published : 2011
DOI: 10.1039/c0dt01075h
Abstract
There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer’s disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands..
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Funding Acknowledgements
This article is dedicated to two inspirational mentors, Prof. Jack Harrowfield and Prof. Jonathan Dilworth in celebration of their relatively recent 'significant' birthdays.<SUP>106,107</SUP> Jack introduced the author to the beauty and creativity of synthetic chemistry whilst Jon introduced the author to its rewarding application to radiopharmaceutical design. The dedicated and talented colleagues cited amongst the references are acknowledged for their vital contributions to the author's research in this area. Financial support from the Australian Research Council and National Health and Medical Research Council is acknowledged.