Journal article

Dietary patterns and risk of breast cancer

L Baglietto, K Krishnan, G Severi, A Hodge, M Brinkman, DR English, C McLean, JL Hopper, GG Giles



BACKGROUND: Evidence is emerging that prudent/healthy dietary patterns might be associated with a reduced risk of breast cancer. METHODS: Using data from the prospective Melbourne Collaborative Cohort Study, we applied principal factor analysis to 124 foods and beverages to identify dietary patterns and estimated their association with breast cancer risk overall and by tumour characteristics using Cox regression. RESULTS: During an average of 14.1 years of follow-up of 20 967 women participants, 815 invasive breast cancers were diagnosed. Among the four dietary factors that we identified, only that characterised by high consumption of fruit and salad was associated with a reduced risk, with ..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was made possible by the contribution of many people, including the original investigators, the Program Manager, and the diligent team who recruited the participants and who continue working on follow-up. We would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (251533, 209057 and 504711) and The National Breast Cancer Foundation and was further supported by infrastructure provided by The Cancer Council Victoria. JLH is a NHMRC Australia Fellow. LB conceived the study objectives, designed and performed the statistical analyses and prepared the first draft of the article; KK collaborated on the statistical analyses and prepared of the first draft of the article; GS conceived the study objectives, contributed in interpreting the study results and in writing the first draft of the article; AH was responsible for the nutritional program of MCCS, contributed to identify the dietary patterns and to interpret the study results; MB contributed to interpret the study results; CM reviewed the original tumour slides and assessed ER and PR status; DRE, JLH and GGG are the principal investigators of MCCS. All authors contributed to the writing and editing of the final version of the manuscript.