Journal article
Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis
WJ van Zuylen, V Garceau, A Idris, K Schroder, KM Irvine, JE Lattin, DA Ovchinnikov, AC Perkins, AD Cook, JA Hamilton, PJ Hertzog, KJ Stacey, S Kellie, DA Hume, MJ Sweet
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Open access
Abstract
Background: The ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in macrophages, which are key cellular regulators of innate immunity. Methodology/Principal Findings: Multiple members of the Slfn family were up-regulated in mouse bone marrow-derived macrophages (BMM) by the Toll-like Receptor (TLR)4 agonist lipopolysaccharide (LPS), the TLR3 agonist Poly(I:C), and in disease-affected joints in the collagen-induced model of rheumatoid arthritis. Of these, the most inducible was Slfn4. TLR agonist..
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Funding Acknowledgements
This work was supported by funding from the Cooperative Research Centre for Chronic Inflammatory Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.