Divergent Roles of Glutathione Peroxidase-1 (Gpx1) in Regulation of Leukocyte-Endothelial Cell Interactions in the Inflamed Cerebral Microvasculature

Abstract

Please cite this paper as: Wong, Abeynaike, Crack and Hickey (2011). Divergent Roles of Glutathione Peroxidase-1 (Gpx1) in Regulation of Leukocyte-Endothelial Cell Interactions in the Inflamed Cerebral Microvasculature. Microcirculation18 (1), 12-23.Objective: The aim of this study was to assess the ability of Gpx1 to regulate leukocyte-endothelial cell interactions in the cerebral microcirculation under inflammatory conditions associated with oxidative stress.Methods: To induce cerebral inflammation, wild-type and Gpx1-/- mice underwent systemic treatment with TNF or transient focal cerebral ischemia via MCAO. Leukocyte rolling and adhesion in cerebral postcapillary venules were assessed by..