Journal article

The Test of Everyday Attention Reveals Significant Sustained Volitional Attention and Working Memory Deficits in Friedreich Ataxia

Felicity Klopper, Martin B Delatycki, Louise A Corben, John L Bradshaw, Gary Rance, Nellie Georgiou-Karistianis

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | CAMBRIDGE UNIV PRESS | Published : 2011

Abstract

Sustained volitional attention and working memory capacity was examined for the first time in people with Friedreich ataxia (FRDA). We administered subtests of the Test of Everyday Attention to 16 individuals with molecularly confirmed FRDA and gender-, age-, and IQ-matched controls. Clinically significant impairment in working memory and sustained volitional attention was evident. Working memory deficits correlated significantly with GAA repeat number on the shorter allele of the FXN gene, and separately, with disease severity, as measured by the Friedreich Ataxia Rating Scale score. Sustained volitional attention was not correlated with disease parameters, suggesting that this impairment m..

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