Journal article
No evidence of MMTV-like env sequences in specimens from the Australian Breast Cancer Family Study
DJ Park, MC Southey, GG Giles, JL Hopper
Breast Cancer Research and Treatment | SPRINGER | Published : 2011
Abstract
Numerous independent groups from a range of countries have reported a high prevalence of Mouse Mammary Tumour Virus (MMTV)-like env sequences in human breast cancer specimens, including a prevalence of almost 40% in Australia. MMTV-like sag sequences and a completely integrated provirus have also been described. Recently, it was reported that MMTV is capable of productive infection of human breast cells in vitro. Conclusive demonstration of an association between MMTV and human breast cancer has remained elusive, and negative findings from a number of independent studies have questioned the role of MMTV as an aetiological agent. We used breast cancer specimens from women in the Australian Br..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We would like to thank the women who participate in this study and gave consent for access to their tumour samples. This study was supported by the NHMRC Australia Fellowship number 466668 awarded to JLH, who is also a Victorian Breast Cancer Research Consortium Group Leader. MCS is a National Health and Medical Research Council Senior Research Fellow and a Victorian Breast Cancer Research Consortium Group Leader. The authors would like to thank Ms Veronika Gazdik for histological assistance. The ABCFS has been funded by NHMRC, the Victorian Health Promotion Foundation, and the NSW Cancer Council.