Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals
Christopher A Reid, Tae Hwan Kim, Samuel F Berkovic, Steven Petrou
EPILEPSIA | WILEY | Published : 2011
PURPOSE: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varying seizure susceptibility. METHODS: Three mouse models were used: an absence seizure model based on the knockin of a human GABA(A) γ2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain. Electrocorticography (ECoG) studies were recorded to determine SWDs during hypoglycemia induced by insulin or overnight fast..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This study was supported by the National Health and Medical Research Council of Australia (Grant numbers 400121 & 628520). CAR was also supported by an Australian Future Fellowship, Australian Research Council (#FT0990628).