Journal article

Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals

Christopher A Reid, Tae Hwan Kim, Samuel F Berkovic, Steven Petrou

EPILEPSIA | WILEY | Published : 2011


PURPOSE: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varying seizure susceptibility. METHODS: Three mouse models were used: an absence seizure model based on the knockin of a human GABA(A) γ2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain. Electrocorticography (ECoG) studies were recorded to determine SWDs during hypoglycemia induced by insulin or overnight fast..

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