Journal article
Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial
K Leslie, PS Myles, MTV Chan, A Forbes, MJ Paech, P Peyton, BS Silbert, E Williamson
Anesthesia and Analgesia | Published : 2011
Abstract
BACKGROUND: There is a plausible pathophysiologic rationale for increased long-term cardiovascular morbidity and mortality in patients receiving significant exposure to nitrous oxide. However, this relationship has not been established clinically. The ENIGMA trial randomized 2050 patients having noncardiac surgery lasting more than 2 hours to nitrous oxide-based or nitrous oxide-free anesthesia. We conducted a follow-up study of the ENIGMA patients to evaluate the risk of cardiovascular events in the longer term. METHODS: The trial case report forms and medical records of all study patients were reviewed. The date and cause of death and occurrence of myocardial infarction or stroke were reco..
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Awarded by Chinese University of Hong Kong
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This study was supported by a project grant from the Australian and New Zealand College of Anaesthetists and a direct grant for research from the Chinese University of Hong Kong (project #2041315). The ENIGMA Trial was funded by the National Health and Medical Research Council of Australia (236956).