Fractal analysis of retinal microvasculature and coronary heart disease mortality
Gerald Liew, Paul Mitchell, Elena Rochtchina, Tien Yin Wong, Wynne Hsu, Mong Li Lee, Alan Wainwright, Jie Jin Wang
EUROPEAN HEART JOURNAL | OXFORD UNIV PRESS | Published : 2011
AIM: Fractal analysis provides a global assessment of vascular network architecture. We examined the relationship of retinal vascular fractal dimension (D(f)) with coronary heart disease (CHD) mortality. METHODS AND RESULTS: We examined the relationship of D(f) with 14-year CHD mortality in a prospective, population-based cohort of 3303 participants aged 49 years or older. D(f) was measured from digitized fundus photographs using computer-automated methods; CHD mortality was documented from Australian National Death Index records. Mean D(f) in this population was 1.441 (standard deviation, 0.024). Over 14 years, there were 468 (14.2%) CHD deaths. Participants with suboptimal D(f) (lowest and..View full abstract
Awarded by Singapore Bioimaging Consortium
Awarded by National Medical Research Council
Awarded by Australian National Health & Medical Research Council (NHMRC)
This work was supported by Singapore Bioimaging Consortium (SBIC RP C-011/2006); National Medical Research Council (NMRC/STaR/0003/2008); Australian National Health & Medical Research Council (NHMRC, Project grant IDs: 153948, 211069, and 302068); Pfizer Australia (Cardiovascular Lipid Grant 2007); and Diabetes Australia Research Trust (DART Grant 2007).