Journal article
An investigation of the relationship between cortical connectivity and schizotypy in the general population
MT Nelson, ML Seal, LJ Phillips, AH Merritt, R Wilson, C Pantelis
Journal of Nervous and Mental Disease | Published : 2011
Abstract
Recent neuroimaging investigations have identified a relationship between psychotic symptoms in schizophrenia and abnormal brain connectivity. On the basis of the continuum model of psychosis, it was hypothesized that schizotypal traits in healthy control participants would be associated with relatively impaired frontotemporal white matter health as assessed using diffusion tensor imaging. Twenty-one participants (12 women and 9 men aged 18 to 58 years) completed the Schizotypal Personality Questionnaire (SPQ) and underwent diffusion-weighted magnetic resonance imaging scanning as part of a larger study. White matter integrity for the major association fibre tracts was assessed using standar..
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
Funding Acknowledgements
This study was supported by the Australian Schizophrenia Research Bank (ASRB), which is supported by the National Health and Medical Research Council of Australia (NHMRC; ID: 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. Professor Pantelis is an NHMRC Senior Principal Research Fellow (ID: 628386), and his research is supported by an NHMRC program grant (ID: 566529).The authors thank the Neuropsychiatry Imaging Laboratory, managed by Ms Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria, for facilitating the neuroimaging analysis.