Neuroanatomical Abnormalities That Predate the Onset of Psychosis A Multicenter Study
Andrea Mechelli, Anita Riecher-Roessler, Eva M Meisenzahl, Stefania Tognin, Stephen J Wood, Stefan J Borgwardt, Nikolaos Koutsouleris, Alison R Yung, James M Stone, Lisa J Phillips, Patrick D McGorry, Isabel Valli, Dennis Velakoulis, James Woolley, Christos Pantelis, Philip McGuire
Archives of General Psychiatry | AMER MEDICAL ASSOC | Published : 2011
CONTEXT: People experiencing possible prodromal symptoms of psychosis have a very high risk of developing the disorder, but it is not possible to predict, on the basis of their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between individuals at ultra-high risk (UHR) for psychosis who later develop psychotic disorder and those who do not. However, the samples examined to date have been small, and the findings have been inconsistent. OBJECTIVE: To assess brain structure in individuals at UHR for psychosis in a larger and more representative sample than in previous studies by combini..View full abstract
Awarded by Medical Research Council
This study was supported by a National Alliance for Research on Schizophrenia and Depression Independent Investigator Award (Dr Mechelli).