Journal article

Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis

Emre Bora, Alex Fornito, Joaquim Radua, Mark Walterfang, Marc Seal, Stephen J Wood, Murat Yuecel, Dennis Velakoulis, Christos Pantelis

Schizophrenia Research | ELSEVIER | Published : 2011

Abstract

Despite an increasing number of published voxel based morphometry studies of schizophrenia, there has been no adequate attempt to examine gray (GM) and white matter (WM) abnormalities and the heterogeneity of published findings. In the current article, we used a coordinate based meta-analysis technique to simultaneously examine GM and WM abnormalities in schizophrenia and to assess the effects of gender, chronicity, negative symptoms and other clinical variables. 79 studies meeting our inclusion criteria were included in the meta-analysis. Schizophrenia was associated with GM reductions in the bilateral insula/inferior frontal cortex, superior temporal gyrus, anterior cingulate gyrus/medial ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

AF was supported by a NHMRC CJ Martin Fellowship (ID: 454797). SW was supported by Clinical Career Development Award from the NHMRC. MY was supported by a National Health and Medical Research Council (NHMRC) clinical career development award (ID: 509345). CP was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and by NHMRC Program Grant (ID: 566529).