Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies
Nitin Gogtay, Nora S Vyas, Renee Testa, Stephen J Wood, Christos Pantelis
SCHIZOPHRENIA BULLETIN | OXFORD UNIV PRESS | Published : 2011
Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of onset in late adolescence. Late adolescence may reflect a critical period in brain development making it particularly vulnerable for the onset of psychopathology. Neuroimaging studies that focus on this age range may provide unique insights into the onset and course of psychosis. In this review, we examine the evidence from 2 unique longitudinal cohorts that span the ages from early childhood through young adulthood; a study of childhood-onset schizophrenia where patients and siblings are followed from ages 6 through to their early twenties, and an ultra-high risk study where subjects (mean age of 19..View full abstract
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Awarded by NHMRC
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
N.S.V. is supported by the Fulbright Distinguished Scholar Award by the US-UK Fulbright Commission. C. P. is supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and NHMRC Program Grants (ID: 350241, 566529).