The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: Replication in schizophrenia and extension to bipolar disorder with psychosis
Tetsufumi Kanazawa, Gursharan Chana, Stephen J Glatt, Hideya Mizuno, Eliezer Masliah, Hiroshi Yoneda, Ming T Tsuang, Ian P Everall
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | WILEY | Published : 2008
While microarray studies are generating novel insights into the etiology of major psychiatric disorders, the validation of microarray-identified candidate genes and their role in the causality of these disorders has been less often studied. We have previously demonstrated, by microarray, up-regulation of SELENBP1 in the brain and blood of patients with schizophrenia. The main aim of the current study was to validate this finding using quantitative real-time PCR (QPCR) in an independent brain cohort that included patients with bipolar disorder. Our sample consisted of mRNAs from the dorsolateral prefrontal cortex (dlPFC) of 34 schizophrenic patients, 33 bipolar disorder patients (including 20..View full abstract
Postmortem brain tissue was donated by the Stanley Medical Research Institute's brain collection courtesy of Drs. Michael B. Knable, E. Fuller Torrey, MareeJ. Webster, and Robert H. Yolken. The authors appreciate the useful suggestions from Sharon Chandler Ph.D., Dr. Roberta Marongiu, and colleagues in the Department of Neuropsychiatry, Osaka Medical College. This work was conducted while Dr. Kanazawa was a Visiting Scholar at the Center for Behavioral Genomics in the Department of Psychiatry at the University of California, San Diego, and was funded by the Department of Neuropsychiatry, Osaka Medical College.