Journal article
Closed-loop seizure control with very high frequency electrical stimulation at seizure onset in the gaers model of absence epilepsy
TS Nelson, CL Suhr, DR Freestone, A Lai, AJ Halliday, KJ McLean, AN Burkitt, MJ Cook
International Journal of Neural Systems | WORLD SCIENTIFIC PUBL CO PTE LTD | Published : 2011
Abstract
A closed-loop system for the automated detection and control of epileptic seizures was created and tested in three Genetic Absence Epilepsy Rats from Strasbourg (GAERS) rats. In this preliminary study, a set of four EEG features were used to detect seizures and three different electrical stimulation strategies (standard (130 Hz), very high (500 Hz) and ultra high (1000 Hz)) were delivered to terminate seizures. Seizure durations were significantly shorter with all three stimulation strategies when compared to non-stimulated (control) seizures. We used mean seizure duration of epileptiform discharges persisting beyond the end of electrical stimulation as a measure of stimulus efficacy. When c..
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Funding Acknowledgements
The authors wish to acknowledge the support of the State Government of Victoria through the Science and Technology Innovation Initiative. The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program and the Helen Macpherson Smith Trust. The research could also not have been achieved without the cooperation of Professor Terry O'Brien and his research group at the Royal Melbourne Hospital for the supply of GAERS rats.