Journal article
Glutamate cysteine ligase (GCL) and self reported depression: An association study from the HUNT
M Berk, S Johansson, NR Wray, L Williams, C Olsson, J Haavik, O Bjerkeset
Journal of Affective Disorders | ELSEVIER | Published : 2011
Abstract
Background: There is increasing evidence suggesting oxidative stress may play a role in the aetiology of depression. Glutathione is the brain's predominant free radical scavenger, and associated polymorphisms of the glutamate cysteine ligase (GCL) gene have been reported for related psychiatric disorders. The aim of the study was to investigate candidate polymorphisms of GCL validated in schizophrenia and their association with current state depression, as measured by the Hospital Anxiety and Depression Scale (HADS). Methods: Polymorphisms were genotyped on 983 cases and 967 controls selected from a population sample of adults participating in the Nord-Trøndelag Health Study. Cases were the ..
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Funding Acknowledgements
[ "Costs associated with the genetic analysis were partly funded by the Research Council of Norway, Heise Vest, Health Trust Nord-Trondelag Research Foundation, and The University of Melbourne.", "Dr Lana Williams has received research support from an unrestricted educational grant from Eli Lilly.", "Professor Michael Berk has received Grant/Research Support from the Stanley Medical Research Foundation, MBE, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma, Servier and Astra Zeneca. He has been a paid consultant for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck and Pfizer and a paid speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Organon, Pfizer, Sanofi Synthelabo, Solvay and Wyeth." ]