Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation
Nicole KL Lee, Jarrod PJ Skinner, Jeffrey D Zajac, Helen E MacLean
American Journal of Physiology - Endocrinology and Metabolism | AMER PHYSIOLOGICAL SOC | Published : 2011
The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. We previously showed that expression of Odc1 is decreased in muscle from AR knockout male mice. In this study, we show in vivo that Odc1 expression is also decreased >60% in muscle from male muscle-specific AR knockout mice. In normal muscle homeostasis, Odc1 expression is regulated by age and sex, reflecting testosterone levels, as muscle of adult male mice expresses high levels of Odc1 compared ..View full abstract
Awarded by National Health and Medical Research Council (Australia)
This research was supported by National Health and Medical Research Council (Australia) Grants 350334 and 359226, the Sir Edward Dunlop Medical Research Foundation, and an Eva and Les Erdi Major Research Grant.