Journal article

Obsessive-Compulsive Disorder, Impulse Control Disorders and Drug Addiction Common Features and Potential Treatments

Leonardo F Fontenelle, Sanne Oostermeijer, Ben J Harrison, Christos Pantelis, Murat Yuecel

Drugs | ADIS INT LTD | Published : 2011


The basic concepts underlying compulsive, impulsive and addictive behaviours overlap, which may help explain why laymen use these expressions interchangeably. Although there has been a large research effort to better characterize and disentangle these behaviours, clinicians and scientists are still unable to clearly differentiate them. Accordingly, obsessive-compulsive disorder (OCD), impulse control disorders (ICD) and substance-related disorders (SUD) overlap on different levels, including phenomenology, co-morbidity, neurocircuitry, neurocognition, neurochemistry and family history. In this review we summarize these issues with particular emphasis on the role of the opioid system in the p..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

A/Prof. Leonardo F. Fontenelle was supported by an Endeavour Research Fellowship (postdoctoral research) from the Department of Education, Employment and Workplace Relations (Australia), and Bolsa de Produtividade em Pesquisa, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil); Dr Ben J. Harrison was supported by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (ID 628509); Prof. Christos Pantelis was supported by an NHMRC Senior Principal Research Fellowship (ID 628386) and NHMRC Program Grants (ID 566529); Dr Murat Yucel was supported by an NHMRC Clinical Career Development Award (ID 509345).