Journal article

Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity

L Kostenko, L Kjer-Nielsen, I Nicholson, F Hudson, A Lucas, B Foley, K Chen, K Lynch, J Nguyen, AHB Wu, BD Tait, R Holdsworth, S Mallal, J Rossjohn, M Bharadwaj, J McCluskey

TISSUE ANTIGENS | WILEY-BLACKWELL | Published : 2011

Abstract

HLA-B57 and HLA-B58 are major histocompatibility class (MHC)-I allotypes that are potentially predictive of important clinical immune phenotypes. HLA-B*5701 is strongly associated with hypersensitivity to the HIV drug abacavir, liver toxicity from the antibiotic flucloxacillin and is a marker for slow progression of HIV AIDS. HLA-B*5801 is associated with hypersensitivity to allopurinol used to treat hyperuricaemia and recurrent gout. Here we describe a monoclonal antibody (mAb) specific for HLA-B57 and HLA-B58 that provides an inexpensive and sensitive screen for these MHC-I allotypes. The usefulness of HLA-B57 screening for prediction of abacavir hypersensitivity was shown in three indepen..

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