Journal article

General and Specific Functional Connectivity Disturbances in First-Episode Schizophrenia During Cognitive Control Performance

Alex Fornito, Jong Yoon, Andrew Zalesky, Edward T Bullmore, Cameron S Carter

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2011

Abstract

BACKGROUND: Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task. METHODS: Functional connectivity during cognitive control performance was assessed between each pair of 78 brain regions in 23 patients and 25 control subjects. Network properties examined were regi..

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University of Melbourne Researchers