Journal article

Quantum measurement and orientation tracking of fluorescent nanodiamonds inside living cells

LP McGuinness, Y Yan, A Stacey, DA Simpson, LT Hall, D Maclaurin, S Prawer, P Mulvaney, J Wrachtrup, F Caruso, RE Scholten, LCL Hollenberg

Nature Nanotechnology | NATURE PUBLISHING GROUP | Published : 2011

Abstract

Fluorescent particles are routinely used to probe biological processes. The quantum properties of single spins within fluorescent particles have been explored in the field of nanoscale magnetometry, but not yet in biological environments. Here, we demonstrate optically detected magnetic resonance of individual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measure their location, orientation, spin levels and spin coherence times with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with effective 1° angular precision over acquisition times of 89 ms. The quantum..

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Grants

Awarded by Australian Research Council


Awarded by Discovery Project scheme


Awarded by Federation Fellowship Scheme


Funding Acknowledgements

The authors thank F. Jelezko and A. Johnston for helpful discussions and advice, and S. Szilagyi for technical assistance. This work was supported by the Australian Research Council under the Centre of Excellence scheme (CE110001027), the Discovery Project scheme (DP0770715 and DP0877360), the Federation Fellowship Scheme (FF0776078) and the Baden-Wuerttemberg Foundation.