Atypical (RIO) protein kinases from Haemonchus contortus - Promise as new targets for nematocidal drugs
Bronwyn E Campbell, Peter R Boag, Andreas Hofmann, Cinzia Cantacessi, Conan K Wang, Paul Taylor, Min Hu, Zia-ud-Din Sindhu, Alex Loukas, Paul W Sternberg, Robin B Gasser
BIOTECHNOLOGY ADVANCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2011
Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of n..View full abstract
Funding from the Australian Research Council (ARC) is gratefully acknowledged (RBG). PRB is supported by funding from the National Health and Medical Research Council (NHMRC).