Journal article
The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats
BL Ash, SD Zanatta, SJ Williams, AJ Lawrence, E Djouma
Regulatory Peptides | ELSEVIER SCIENCE BV | Published : 2011
Abstract
Background/objective: The galanin-3 receptor (GALR3) subtype has been identified as having a role in both feeding behaviour and the regulation of emotional states including anxiety. Despite the evidence for an association between galanin and alcohol, the current study is the first to explore the direct role of GALR3 in this context. The present study investigated the potential of the novel selective GALR3 antagonist, SNAP 37889, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. This was achieved through a number of behavioural paradigms testing for anxiety, along with the operant self-administration model. Results: Overall, male iP rats tr..
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Funding Acknowledgements
The authors would like to thank the Faculty of Health Sciences, La Trobe University for providing funding for this project. AJL is a Senior Research Fellow of the NHMRC Australia.