Polymersome-loaded capsules for controlled release of DNA

H Lomas; APR Johnston; GK Such; Z Zhu; K Liang; MP Van Koeverden; S Alongkornchotikul; F Caruso

Journal article

Polymersome-loaded capsules for controlled release of DNA

H Lomas, APR Johnston, GK Such, Z Zhu, K Liang, MP Van Koeverden, S Alongkornchotikul, F Caruso

Small | Published : 2011

DOI: 10.1002/smll.201100744

Download PDF

Abstract

The formation of a novel drug-delivery carrier for the controlled release of plasmid DNA that comprises layer-by-layer polymer capsules subcompartmentalized with pH-sensitive nanometer-sized polymersomes is reported. The amphiphilic diblock copolymer poly(oligoethylene glycol methacrylate)-block-poly(2-(diisopropylamino)ethyl methacrylate) forms polymersomes at physiological pH, but transitions to unimeric polymer chains upon acidification to cellular endocytic pH. These polymersomes can thus release an encapsulated payload in response to a change in pH from physiological to endocytic conditions. Multicomponent layer-by-layer capsules are formed by exploiting the ability of tannic acid to ac..

View full abstract

University of Melbourne Researchers

Georgina Such Author

Martin van Koeverden Author

Frank Caruso Author

Related Projects (4)

COLORECTAL CANCER - MOLECULAR BASIS TO TARGETED THERAPEUTICS

Cancer of the colon and rectum is the most common form of cancer in Australia. Over 12,000 people are diagnosed each year with colorectal ca..

COLORECTAL CANCER - MOLECULAR BASIS TO TARGETED THERAPEUTICS

Cancer of the colon and rectum is the most common form of cancer in Australia. Over 12,000 people are diagnosed each year with colorectal ca..

Engineering and Assembly of Bioinspired Nanostructured Materials

Scientific and technological advances at the frontiers of nano- and bio-technology are poised to revolutionise healthcare and medicine. This..

BUILDING MOLRCULARY ENGINEERED POLYMER NANOMATERIALS

The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This..

Grants

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the ARC and NHMRC under the Federation Fellowship (FF0776078), Discovery Project (DP0877360), and Program Grant (487922) schemes.