Journal article

Preventing the Second Episode: A Systematic Review and Meta-analysis of Psychosocial and Pharmacological Trials in First-Episode psychosis

Mario Alvarez-Jimenez, Alexandra G Parker, Sarah E Hetrick, Patrick D McGorry, John F Gleeson

SCHIZOPHRENIA BULLETIN | OXFORD UNIV PRESS | Published : 2011

Abstract

OBJECTIVE: The majority of first-episode psychosis (FEP) patients reach clinical remission; however, rates of relapse are high. This study sought to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of pharmacological and non-pharmacological interventions to prevent relapse in FEP patients. METHODS: Systematic review and meta-analysis of RCTs. RESULTS: Of 66 studies retrieved, 18 were eligible for inclusion. Nine studies investigated psychosocial interventions and 9 pharmacological treatments. The analysis of 3 RCTs of psychosocial interventions comparing specialist FEP programs vs treatment as usual involving 679 patients d..

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