Journal article
Quantitative 177Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system
JM Beauregard, MS Hofman, JM Pereira, P Eu, RJ Hicks
Cancer Imaging | BMC | Published : 2011
Abstract
Purpose: The combination of single photon emission computed tomography (SPECT) and computer tomography (CT) that incorporates iterative reconstruction algorithms with attenuation and scatter correction should facilitate accurate non-invasive quantitative imaging. Quantitative SPECT (QSPECT) may improve diagnostic ability and could be useful for many applications including dosimetry assessment. Using 177Lu, we developed a QSPECT method using a commercially available SPECT/CT system. Methods: Serial SPECT of 177Lu sources (89-12,400 MBq) were acquired with multiple contiguous energy windows along with a co-registered CT, and were reconstructed using an iterative algorithm with attenuation and ..
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Funding Acknowledgements
The authors are grateful to Micheal G. Stabin from the Department of Radiology and Radiological Sciences, Vanderbilt University (Nashville, TN), for reviewing this paper. Jean-Mathieu Beauregard was supported by a fellowship bursary award from Laval University (Quebec, Canada). Professor Hicks is the recipient of a Victorian Government Translational Research Grant through the Victorian Cancer Agency to study genomic and dosimetric factors predictive of response of neuroendocrine tumour to peptide receptor radionuclide therapy.