Journal article
The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery
CF Royse, DT Andrews, SN Newman, J Stygall, Z Williams, J Pang, AG Royse
Anaesthesia | Published : 2011
Abstract
We investigated the influence of either propofol or desflurane on the incidence of postoperative cognitive dysfunction in a randomised trial of 180 patients undergoing coronary artery bypass surgery. The primary outcome was incidence of postoperative cognitive dysfunction at 3months, defined as ≥1 SD deterioration in two or more of 12 neurocognitive tests. Secondary outcomes included early postoperative cognitive dysfunction (between days three and seven), delirium on day one, morbidity and length of hospital stay. Early postoperative cognitive dysfunction was significantly higher with propofol compared with desflurane (56/84 (67.5%) vs 41/83 (49.4%), respectively, p=0.018), but this effect ..
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Funding Acknowledgements
The authors thank the many anaesthetists, surgeons, nursing and administrative staff who assisted in the conduct of the study. Specifically, we thank Matthew Sheppard, Research Assistant, University of Melbourne, Australia; and Linda Copland, R.N. research nurse, University of Melbourne, Australia, for assistance with data collection, and Baxter Healthcare for funding the study.