Journal article
The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy
KA Connelly, A Advani, S Kim, SL Advani, M Zhang, KE White, YM Kim, C Parker, K Thai, H Krum, DJ Kelly, RE Gilbert
Journal of Hypertension | Published : 2011
Abstract
Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart. Methods: Using confocal microscopy, site-specific markers and transmission electron microscopy we assessed the location of the pro(renin) receptor in the heart at both cellular/sub-cellular levels. We assessed pro(renin) recep..
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Awarded by NHMRC
Funding Acknowledgements
Sources of support: This work was supported by grants from the Canadian Institutes of Health Research (CIHR) and Novartis Pharma. K. A. C. was supported by a HSF Canada Phase 1 clinician scientist award, a TACTICS scholarship (Canada) and a NHMRC Neil Hamilton Fairley scholarship ID 440712. R. E. G. is a Canada Research Chair in Diabetes Complications and this work was supported, in part, thanks to the Canadian Diabetes Association and the Canada Research Chair Program. Dr A. A. is a Canadian Diabetes Association Clinician Scientist. Confocal microscopy was performed at the BioImaging Facility of St. Michael's Hospital, Toronto, Canada.Conflict of interest: K. A. C., H. K., R. E. G. and D.J.K. have received honoraria and research support from Novartis, the manufacturers of aliskiren.