Journal article

Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy

Iain Beehuat Tan, Tatiana Ivanova, Kiat Hon Lim, Chee Wee Ong, Niantao Deng, Julian Lee, Sze Huey Tan, Jeanie Wu, Ming Hui Lee, Chia Huey Ooi, Sun Young Rha, Wai Keong Wong, Alex Boussioutas, Khay Guan Yeoh, Jimmy So, Wei Peng Yong, Akira Tsuburaya, Heike Grabsch, Han Chong Toh, Steven Rozen Show all

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2011

Abstract

BACKGROUND & AIMS: Gastric cancer (GC) is a heterogeneous disease comprising multiple subtypes that have distinct biological properties and effects in patients. We sought to identify new, intrinsic subtypes of GC by gene expression analysis of a large panel of GC cell lines. We tested if these subtypes might be associated with differences in patient survival times and responses to various standard-of-care cytotoxic drugs. METHODS: We analyzed gene expression profiles for 37 GC cell lines to identify intrinsic GC subtypes. These subtypes were validated in primary tumors from 521 patients in 4 independent cohorts, where the subtypes were determined by either expression profiling or subtype-spe..

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Awarded by BMRC


Awarded by NMRC


Awarded by NIH


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

The authors disclose the following: As mandated for research projects funded by the Singapore government, a patent application covering this work has been filed by Exploit Technologies Pte Ltd, the intellectual property arm of the Agency for Science Technology and Research, Singapore.Supported by grants from BMRC 05/1/31/19/423 (to P.T.), NMRC grant TCR/001/2007 (to P.T.), and a Duke-National University of Singapore core grant (to P.T.). Also supported by grants from the National Research Foundation of Singapore and American Society of Clinical Oncology Conquer Cancer Foundation (to I.B.T.). Cohort 3 was funded by NIH R01 (to J.-S.L.). J.A.A. is supported by a program grant from the University of Texas MD Anderson Cancer Center; the Park, Dallas, Cantu, and Smith families; Kevin and Sultan funds; and Rivercreek and Schecter Private Foundations. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.