Journal article

Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women

Itamar Levinger, Kirsten F Howlett, Jonathan Peake, Andrew Garnham, David L Hare, George Jerums, Steve Selig, Craig Goodman

Exercise Immunology Review | W W F VERLAGSGESELLSCHAFT GMBH | Published : 2010


AIMS: This study investigated the association between the basal (rest) insulin-signaling proteins, Akt, and the Akt substrate AS160, metabolic risk factors, inflammatory markers and aerobic fitness, in middle-aged women with varying numbers of metabolic risk factors for type 2 diabetes. METHODS: Sixteen women (n=16) aged 51.3 +/- 5.1 (mean +/- SD) years provided muscle biopsies and blood samples at rest. In addition, anthropometric characteristics and aerobic power were assessed and the number of metabolic risk factors for each participant was determined (IDF criteria). RESULTS: The mean number of metabolic risk factors was 1.6 +/- 1.2. Total Akt was negatively correlated with IL-1beta (r = ..

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