Approaching the Promise of Operational Tolerance in Clinical Transplantation
G Alex Bishop, Francesco L Ierino, Alexandra F Sharland, Bruce M Hall, Stephen I Alexander, Mauro S Sandrin, P Toby Coates, Geoffrey W McCaughan
TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Long-term acceptance of transplanted organs without requirement for indefinite immunosuppression remains the ultimate goal of transplant clinicians and scientists. This clinical state of allograft acceptance termed "operational tolerance" has been elusive in routine practice. However, there are published reports of recipients where immunosuppression has been discontinued, by intention or patient noncompliance, in which the outcome is a nondestructive immune response and normal function. The question now arises how clinical operational tolerance might be achieved in the majority of recipients. This review provides an overview of current approaches to achieve operational tolerance, including t..View full abstract
This work was supported by the National Health and Medical Research Council of Australia and by the Microsearch Foundation of Australia.