Antibody responses to glycolipid-borne carbohydrates require CD4( ) T cells but not CD1 or NKT cells
Dale Christiansen, Hilary A Vaughan, Julie Milland, Natalie Dodge, Effie Mouhtouris, Mark J Smyth, Dale I Godfrey, Mauro S Sandrin
IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2011
Naturally occurring anti-carbohydrate antibodies play a major role in both the innate and adaptive immune responses. To elicit an anti-carbohydrate immune response, glycoproteins can be processed to glycopeptides and presented by the classical antigen-presenting molecules, major histocompatibility complex (MHC) Class I and II. In contrast, much less is known about the mechanism(s) for anti-carbohydrate responses to glycolipids, although it is generally considered that the CD1 family of cell surface proteins presents glycolipids to T cells or natural killer T (NKT) cells. Using model carbohydrate systems (isogloboside 3 and B blood group antigen), we examined the anti-carbohydrate response on..View full abstract
This work was supported by funds obtained from the National Health and Medical Research Council of Australia. MSS, MJS and DIG are supported by NHMRC Research Fellowships. We thank David Jackson for mass spectroscopy analysis.