Journal article

Antibody responses to glycolipid-borne carbohydrates require CD4( ) T cells but not CD1 or NKT cells

Dale Christiansen, Hilary A Vaughan, Julie Milland, Natalie Dodge, Effie Mouhtouris, Mark J Smyth, Dale I Godfrey, Mauro S Sandrin

IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2011

Abstract

Naturally occurring anti-carbohydrate antibodies play a major role in both the innate and adaptive immune responses. To elicit an anti-carbohydrate immune response, glycoproteins can be processed to glycopeptides and presented by the classical antigen-presenting molecules, major histocompatibility complex (MHC) Class I and II. In contrast, much less is known about the mechanism(s) for anti-carbohydrate responses to glycolipids, although it is generally considered that the CD1 family of cell surface proteins presents glycolipids to T cells or natural killer T (NKT) cells. Using model carbohydrate systems (isogloboside 3 and B blood group antigen), we examined the anti-carbohydrate response on..

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