Inflammatory Responses to Individual Microorganisms in the Lungs of Children With Cystic Fibrosis
Catherine Gangell, Samantha Gard, Tonia Douglas, Judy Park, Nicholas de Klerk, Tony Keil, Siobhain Brennan, Sarath Ranganathan, Roy Robins-Browne, Peter D Sly
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2011
BACKGROUND: We hypothesized that the inflammatory response in the lungs of children with cystic fibrosis (CF) would vary with the type of infecting organism, being greatest with Pseudomonas aeruginosa and Staphylococcus aureus. METHODS: A microbiological surveillance program based on annual bronchoalveolar lavage (BAL) collected fluid for culture and assessment of inflammation was conducted. Primary analyses compared inflammation in samples that grew a single organism with uninfected samples in cross-sectional and longitudinal analyses. RESULTS: Results were available for 653 samples from 215 children with CF aged 24 days to 7 years. A single agent was associated with pulmonary infection (≥1..View full abstract
Awarded by National Health and Medical Research Council, Australia
Awarded by Cystic Fibrosis Foundation Trust
This study was supported by grants from the National Health and Medical Research Council, Australia (211912); and the Cystic Fibrosis Foundation Trust (04A0 to P. D. S. and 09AO to S. M. S.). C. G. was funded partly through the Australian Cystic Fibrosis Research Trust. J. P.'s salary was funded by the Cystic Fibrosis Foundation Therapeutics.C. G. received funding from the European Respiratory Society to attend the ERS annual scientific conference to present data in this article. All other authors: No reported conflicts.