Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome
Roger Hart, Dorota A Doherty, Trevor Mori, Rae-Chi Huang, Robert J Norman, Stephen Franks, Deborah Sloboda, Lawrie Beilin, Martha Hickey
Fertility and Sterility | ELSEVIER SCIENCE INC | Published : 2011
OBJECTIVE: To determine prevalence of metabolic syndrome in adolescents with polycystic ovary syndrome (PCOS) and derive features suggestive of propensity for development of metabolic syndrome. DESIGN: Prospective cohort study. SETTING: Population-based cohort of adolescents in Western Australia. PARTICIPANT(S): Metabolic data from 1,377 children aged 14 years, features of PCOS obtained from 244 girls aged 14 to 17 years. INTERVENTION(S): Assessment for features of PCOS and subsequent fasting blood samples. MAIN OUTCOME MEASURE(S): Relationship between features of PCOS and features of metabolic syndrome. RESULT(S): With use of five definitions of metabolic syndrome the maximal prevalence of ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Medical Research Council
Supported by National Health and Medical Research Council (NHMRC) project grant 403968 and by a University of Western Australia Ada Bartholomew grant for the collection of adolescent data and samples. The collection of maternal data and samples was funded by the Women and Infants Research Foundation. The metabolic analyses were funded by a Western Australia Healthway Grant and NHMRC project grant 403981. M.H. is funded by an NHMRC Clinical Career Development Award.