Journal article

Task-Induced Deactivation from Rest Extends beyond the Default Mode Brain Network

Ben J Harrison, Jesus Pujol, Oren Contreras-Rodriguez, Carles Soriano-Mas, Marina Lopez-Sola, Joan Deus, Hector Ortiz, Laura Blanco-Hinojo, Pino Alonso, Rosa Hernandez-Ribas, Narcis Cardoner, Jose M Menchon

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011


Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance i..

View full abstract

University of Melbourne Researchers


Awarded by Fondo de Investigacion Sanitaria (FIS)

Awarded by Ministry of Education and Science of Spain

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This work was supported in part by the Fondo de Investigacion Sanitaria (FIS, I.D. PI050884) and Ministry of Education and Science of Spain ( I. D. SAF2007-62376). BJH is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509). JD and ML-S are members of the Research Group SGR-1450 of the Agency of University and Research Funding Management of the Catalan Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study.