Journal article

Shaping the T-cell repertoire in the periphery

Stacey Allen, Stephen J Turner, Dorothee Bourges, Paul A Gleeson, Ian R van Driel

Immunology and Cell Biology | WILEY | Published : 2011


Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self-reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T-cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T-cell differentiation.